monoamine oxidase-A (MAO-A)
Status:
Tags:
Monoamine ocidase-A (MAO-A) ist ein Einzym, welches an den Enden vom Dendrites des Sympathetic Nervous System (SNS) sitzt und baut hauptsächlich Dopamine, Serotonin, Norepinephrine und Noradrenaline ab.
- demnach führt eine erhöhte MAO-A-Produktion zu einem geringeren Serotoninspiegel.
- MAO-A-Hemmer sind ein wichtiger Bestandteil in einer antidepressiven Therapie.
- Wenn man in einem erwachsenen Nagetier MAO-A Aktivität temporär unterbindet, verringert es impulsive Aggression; macht man das gleiche bei fötalen Nagetieren werden sie zu Nagetieren mit erhöhter impulsiver Aggression
aus Behave
low-activity MAO-A-Variation being referred to as the “warrior gene”
Seite 208 · Position 4175
The effects of MAO-A variants are tiny.
Seite 208 · Position 4181
“In a healthy environment, increased threat sensitivity, poor emotion control and enhanced fear memory in MAOA-L [i.e., the “warrior” variant] men might only manifest as variation in temperament within a ‘normal’ or subclinical range. However, these same characteristics in an abusive childhood environment—one typified by persistent uncertainty, unpredictable threat, poor behavioral modeling and social referencing, and inconsistent reinforcement for prosocial decision making—might predispose toward frank aggression and impulsive violence in the adult.”
Seite 209 · Position 4200
activity individuals were more aggressive than others—but only in circumstances of social exclusion.
Seite 210 · Position 4212
See also
childhood adversity
Aggression
Superlink: Depression
050 🧠Neuroscience
051 ☣Neurobiology
030 🧬Genetics
tags: neurobiology science genetics
Quellen
Chapter 8 Back to When You Were Just a Fertilized Egg
Erstellt: 26-07-21 21:02