AP5
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AP5, or 2-amino-5-phosphonopentanoate, is a synthetic compound that acts as a competitive antagonist of the NMDA (N-Methyl-D-Aspartate) receptor. In the context of NMDA receptors and long-term potentiation (LTP), AP5 is used experimentally to block the NMDA receptor. Since the activation of NMDA receptors is crucial for the induction of LTP, which is a cellular mechanism underlying learning and memory, the application of AP5 can inhibit LTP by preventing calcium ions (Ca2+) from entering the neuron through the NMDA receptor channels.
see also
Tags: neurobiology science
Superlink: 051 ☣Neurobiology 050 🧠Neuroscience
LTP - long term potentiation
NMDA
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Created: 14-10-24 17:25