Glutamate Receptors
AMPA, NMDA (N-Methyl-D-Aspartate), and Kainate Receptors
(In this context, the glutamatergic AMPA receptor is also referred to as a Non-NMDA receptor; Kainate receptor not significant for LTP)
- The AMPA receptor first causes depolarization of the postsynaptic membrane ⇒ Action Potential
- Then actions at the NMDA Receptor
Glutamate
- always acts exitatory
- Based on the given context, it is known that glutamate is a neurotransmitter that plays a role in excitability and synaptic transmission. Glutamate is involved in LTP - long term potentiation, which is the process by which the first burst of NMDA receptor activation causes a prolonged increase in excitability of the Synapse. Glutamate is released by the presynaptic Axon (Nerve) Terminal and binds to receptors on the dendritic spine, leading to increased excitability. Glutamate is also mentioned in the context of fear conditioning in the basolateral Amygdala, where LTP occurs. Additionally, glutamate is associated with dopaminergic systems and the association of a stimulus with a Reward
Classes of glutamate receptors
see also
Tags: neurobiology science HormoneNeurotransmitter
Superlink: 051 ☣Neurobiology 050 🧠Neuroscience
052 🫧Hormone und Neurotransmitter
Source
Created: 31-05-24 16:25
Sources:
LTP - long term potentiation
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