ACTH
adrenocorticotropic hormone
also known as corticotropin
stimulates Glucocorticoids sectrection from the adrenals
ACTH, or adrenocorticotropic hormone (also known as corticotropin), is a hormone that plays a crucial role in the body’s response to stress. It is produced and released by the anterior pituitary gland. The primary function of ACTH is to stimulate the secretion of glucocorticoids, such as Cortisol, from the adrenal glands located above the kidneys.
The process of ACTH release begins in the brain, specifically in the Hypothalamus. When a stressor is sensed or anticipated, the hypothalamus releases corticotropin-releasing hormone (CRH). CRH then travels to the anterior pituitary gland through a specialized circulatory system that connects the hypothalamus and the pituitary gland. Upon reaching the anterior pituitary, CRH triggers the release of ACTH into the bloodstream.
Once released, ACTH travels through the general circulation to the adrenal glands. There, it binds to specific receptors on the surface of the adrenal cortex, stimulating the adrenal glands to produce and release glucocorticoids. These steroid hormones play a significant role in managing stress, affecting various bodily functions including immune response, metabolism, and anti-inflammatory processes.
The regulation of ACTH and Glucocorticoids secretion is a part of the body’s broader stress-response system. This system is essential for maintaining homeostasis and enabling the body to adapt to external and internal stressors. Through its action, ACTH is involved in a wide range of physiological processes that prepare the body to handle stressful situations effectively.
see also
Stress-Response
Stress
Tags: neurobiology science
Superlink: 051 ☣Neurobiology 050 🧠Neuroscience
052 🫧Hormone und Neurotransmitter
Quellen
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CRH
Erstellt: 01-09-22 11:10